SPR videos

Watch our videos to learn about the surface plasmon resonance (SPR) principle

SPR principles

Surface plasmon resonance (SPR) – Principle

See how the SPR technology in Biacore systems allows real-time, label-free detection of biomolecular interactions, providing data on binding kinetics, affinity, specificity, and concentration.

Biacore systems

Biacore SPR systems

Empowering the study of interactions involving virtually any molecule, helping you to generate decisive affinity, kinetics, concentration, specificity, and comparability data, from research to drug discovery and quality control.

Drug discovery at the University of Dundee

See how University of Dundee has applied technologies, such as the Biacore S200 SPR system, to fully characterize the interaction between a drug and challenging targets like G-protein coupled receptors.

Biacore 8K SPR System: first impressions from scientists

Biacore 8K efficiently delivers binding data with the quality you expect, meeting your toughest challenges in small molecule and biotherapeutic screening and characterization.

Biacore T200: push the limits of interaction analysis

With outstanding sensitivity and versatility, Biacore T200 system provides high-quality data for accurate and in-depth studies of biomolecular interactions.

Biacore assay versus Single Radial Immunodiffusion assay

The Biacore T200 flu vaccine assay works with low dose vaccines without interference from oil-based adjuvants. The assay provides increased performance, is easy-to-use, and requires only 2 hours hands-on time.

Access GoldSeal and upgrade your Biacore system

Short movie outlining GE’s GoldSeal program for refurbishment/remanufacturing of Biacore systems with upgraded hardware and software.

Biacore applications

Surface plasmon resonance (SPR) in drug development

SPR using Biacore systems is a key technology for drug candidate screening and characterization. The sensitivity and flexibility of the systems make them essential at every phase in drug discovery.

Value of binding kinetics in drug discovery

A scientist's view on the importance of binding kinetics using Biacore T200 in the development of chemotherapeutics.

Understanding target-compound interactions with SPR

Beactica AB uses surface plasmon resonance (SPR) incorporated in Biacore systems to better understand the nature of binding interactions as well as the binding kinetics in the drug discovery process.

Biacore SPR technology for biosimilar characterization

BioOutsource uses Biacore system for label-free, surface plasmon resonance (SPR)-based characterization of biosimilars. Label-free methods ensure that differences between molecules are genuine rather than labeling artefacts.

Using SPR for structure-function relationship studies

Florida State University uses a Biacore system for quantitative measurement of micromolar interactions and cross-validation of structure-function relationships. Detailed kinetics data gives deeper insights into interactions, creating a link between structure and function.

How-to videos

Biacore 8K SPR system: Product overview

Enjoy this video tour of the major functions of Biacore 8K, a single solution for interaction analysis in both screening and characterization.

Biacore 8K SPR system tutorial: Fragment screening

Biacore 8K and Binding Level Screen is used to efficiently identify promising fragment hits based on binding level and binding behavior. This video guides you through the workflow steps using Biacore 8K software.

Biacore 8K SPR system tutorial: Assay development

This video guides you on how to use the parallel methodology in Biacore 8K for rapid and efficient assay development, regardless of the number of samples.

Biacore 8K SPR system tutorial: Kinetics screening

Molecules like antibodies can share the same affinity but have very different kinetics that might affect drug properties. Biacore 8K efficiently helps you to identify candidates with preferred binding characteristics.

Biacore S200: Clean Screen software workflow

Biacore S200 provides dedicated software support for fragment screening. The first step in a typical workflow aims to eliminate any promiscuous binders. Follow this guide on how to run a Clean Screen assay.

Biacore S200: Binding Level Screen software workflow

Biacore S200 provides dedicated software support for fragment screening. This video guides you through the second step in a typical workflow for a Binding Level Screen assay.

Biacore S200: Affinity Screen software workflow

Biacore S200 provides dedicated software support for fragment screening. This video gives a quick introduction to the third step in a typical workflow, on how to set up an Affinity Screen assay.

Biacore S200: Competition using the ABA-inject software workflow

Biacore S200 provides dedicated software support for fragment screening. The fourth step in a typical workflow is Competition Assay. This video shows how to use the ABA-inject functionality in the software.

Biacore S200: Kinetics software workflow

Biacore S200 is our most sensitive SPR system, well suited for cutting edge applications. This video guides you through the software workflow for a typical kinetic characterization assay.

How to get started with Biacore T200

Biacore T200 is our most versatile SPR system for high-quality characterization of molecular interactions, from ions to viruses. Get a short introduction on how to quickly get started.

Sensorgram comparison evaluation workflow: Biacore T200 Software v3.0

Biacore T200 makes comparability assessment easy by objectively comparing complete binding profiles of samples against that of a reference standard without kinetic modeling.

How to get started with Biacore X100

Biacore X100 is designed for small-scale interaction analysis. This video shows you how to start and prepare your SPR system to perform characterization of molecular mechanisms and interaction pathways.

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