Biacore 8K

High quality binding data meeting the toughest challenges in screening and characterization. 


Discover more, more efficiently


High-quality binding data for confident analysis of drug candidates binding to complex targets.


Eight-needle parallel setup enables screening of 2300 small-molecule fragments in a day.



60 h unattended runtime with method queueing abilities and rapid multirun evaluation.


A single SPR solution for screening, affinity, kinetics, and specificity data.

Performance to meet the toughest applications

Delivering binding data with the quality you expect, meeting your toughest challenges in small molecule and biotherapeutic screening and characterization. Get ready for efficient evaluation of interactions ranging from analysis of small molecules to complex drug targets such as GPCRs and bispecific antibodies.


Analyze challenging drug targets – with ease

System sensitivity and throughput reduces the experimental cycle time, even for complex targets and new drug formats. Analyze the smallest organic compounds with confidence even when interactions are weak. Differentiation of high-affinity binders can be made with ease.


Embrace higher operational efficiency

The flexible eight-channel parallel needle setup boosts efficiency and shortens time to results up to eight-fold compared to single-needle systems. 96 and 384 regular and deep-well microplates can be used and temperature can be maintained at 4°C for analysis of sensitive targets.


Intuitive software interface with maximized overview

Integrated software enables evaluations to be performed with a few simple clicks and is suited for rapid analysis of large screening campaigns or single interactions. The software puts you in control, enabling up to 60 h unattended runtime with queuing abilities and rapid multi-run evaluations.


Dedicated consumables help you reach your goals

Whether you are working with antibodies, tagged proteins, or small molecules, we offer an extensive range of consumables to help you on the road to precise data. Biacore sensor chips, capture kits, reagents, and ready-made buffers are available to support for analysis of a wide range of interactions.


High sensitivity and efficiency.

Delivering binding data with the quality you expect, meeting your toughest challenges in small molecule and biotherapeutic screening and characterization.

Temperature-controlled sample hotel protects sensitive samples in extended runs.
Easy access sensor chip port.
Sample compartment window for easy inspection of the sample processing.
Lower compartment door houses peristaltic pumps for delivery of buffer and water.


Parameter Specification
Detection technology Surface plasmon resonance (SPR) biosensor
Information provided Kinetic and affinity data (ka, kd, KD), specificity, selectivity, and screening data
Data presentation Result tables, result plots, and real-time monitoring of sensorgrams
Analysis time/cycle Typically 2 to 15 min
Automation 60 h unattended operation
Sample type Small molecule drug candidates to high molecular weight proteins (also DNA, RNA,polysaccharides, lipids, cells, and viruses) invarious sample environments (e.g., in DMSO-containing buffers, plasma, and serum)
Required sample volume Injection volume + 20 to 50 μL (application dependent)
Injection volume 1 to 200 μL
Flow-rate range 1 to 100 μL/min
Flow-cell volume 40 nL
Flow-cell height 70 μm
Data collection rate 1 or 10 Hz
Sample/reagent capacity 4 × 96- or 384-well microplates, normal and deep-well
Typical run time Clean screen (1536 samples): 3 h
Binding level screen (384 samples): 4 h
Affinity screen (64 samples): 5 h
Kinetic analysis (64 samples): 4 h
Kinetic screen, single concentration (384 samples): 9 h
2D kinetics (unknown sample): 35 min
Analysis temperature range 4°C to 40°C (maximum 20°C below ambient temperature)
Sample storage 4°C to 40°C (maximum 18°C below ambient temperature)
Sample refractive index range 1.33 to 1.39
In-line reference subtraction Automatic
Number of flow cells 16 in 8 channels
Dimensions (W × H × D) 902 × 860 × 622 mm
Net weight total 127 kg
Mains requirements Processing unit: Autorange voltage 100 to 240 V
Frequency 50/60 Hz
Power consumption, processing unit maximum 350 VA
Association rate constant (ka) Proteins: up to 109 M-1 s-1
LMW molecules: up to 107 M-1 s-1
Dissociation rate constant (kd) 10-6 to 0.5 s-1
Sample concentration ≥ 1 pM
Molecular weight detection No lower limit for organic molecules
Baseline noise Typically < 0.02 RU (RMS)
Baseline drift Typically < 0.3 RU/min
Blank subtracted drift < +/-0.03 RU/min
Immobilized interactant consumption Typically 0.03 to 3 μg/flow cell

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